Transforming precision

Transforming Interventional Ablation
Clinical Trial Interest?
First-in-Human Results at AUA 2026: ALPFA GRAIL Demonstrates Minimally Invasive Treatment for Benign Prostatic Hyperplasia

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Transforming interventional ablation

Transforming Interventional Ablation

Transforming interventional ablation

Transforming Interventional Ablation

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BPH disrupts life in ways men rarely talk about. It’s time for new options. Options men want to choose. Worry-free.

Benign Prostatic Hyperplasia

The prostate is a small gland below the bladder that surrounds the urethra, the tube that carries urine. As men age, it often enlarges, compressing the urethra and making urination more difficult. This condition, called BPH, affects millions of men worldwide.

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Today’s treatments range from surgically removing excess prostate tissue, using heat to shrink or destroy tissue, to placing implants that open the blocked area. While effective for some men, these approaches may also carry risks of bleeding, pain, catheterization, or unintended effects on urinary or sexual function.

14+ Million men actively managed in the US

Only 3% choose a medical procedure

Men hesitate to seek treatment, worried about recovery, changes to sexual function, and the possibility of lasting urinary problems.

What is BPH

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In a young, healthy prostate gland, glandular tissue is compliant, allowing the urethra to expand elastically during urination.

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As a man ages, prostate cells multiply, cluster and form nodules that enlarge the gland, narrowing and compressing the urethra.

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In time, this can lead to benign prostatic hyperplasia, or BPH. A loss of tissue elasticity in the prostate can limit dilation of the urethra during urination.

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This loss of tissue elasticity leads to the lower urinary tract symptoms of BPH that can negatively impact quality of life and require intervention.

What is BPH - alt slider

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In a young, healthy prostate gland, glandular tissue is compliant, allowing the urethra to expand elastically during urination.

Targeted precision

ALPFA Pulsed Field Ablation (PFA) uses targeted electrical energy - without heat - to remodel prostate tissue and restore elasticity. This tissue-selective mechanism is distinct from traditional BPH treatments.

Targeted electrical energy. No heat.
Tissue-selective treatment of the prostate.

No incisions. No punctures.
Uses the body’s natural anatomy.

Designed to reduce risk.
No heat means a lower risk of complications.

ALPFA PFA How it works

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UNDERSTANDING THE PROSTATE: The prostate is made up of two main components: supportive connective tissue and glandular prostate cells, ALPFA GRAIL’s primary target.

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HOW DOES IT WORK: ALPFA GRAIL delivers a precisely controlled pulsed electric field that irreversibly permeabilizes the membranes of prostate cells and breaks them down, while preserving surrounding structures like blood vessels and nerves.

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WHAT HAPPENS AFTER TREATMENT: After treatment, the extra-cellular matrix remains intact, while the targeted prostate cells have been removed.

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RESTORING FUNCTION
The remodeled prostate becomes elastic, allowing the urethra to naturally expand again, helping to restore normal urinary flow.

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Transforming BPH Ablation

Precisely engineered.

The ALPFA GRAIL System is a purpose-built platform integrating energy delivery, catheter design, and software control to enable precise ablation in complex anatomy.

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